Torrent La Zumba Buena

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torrent la zumba buenaAssociation of interleukin-1beta gene polymorphism with development of maternal fever and premature rupture of membrane.
The aim of this study was to investigate whether the interleukin-1beta (IL-1beta) gene polymorphism was associated with premature rupture of membrane (PROM) and maternal fever in early pregnancy. Prospective controlled study was performed on 187 women. The IL-1beta T/T genotype was found to be significantly associated with PROM (OR: 9.2, 95% CI: 1.4-59.2), while T/G and G/G were not (OR: 1.7, 95% CI: 0.4-7.0 and OR: 1.9, 95% CI: 0.6-5.6). IL-1beta G(-511)T polymorphism was not related to an increased risk of preterm birth (OR: 0.9, 95% CI: 0.4-2.4). The T/T genotype was also associated with

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kruppAn anti-inflammatory role for the P2Y12 receptor in human monocytes.
Functional P2Y(12) receptors are expressed in human monocytes and macrophages. We assessed a potential role for these receptors in modulating human monocytic proinflammatory responses. P2Y(12) receptor expression was up-regulated in monocytes isolated from human blood in vitro. Stimulation of monocytes with ATP in the presence of Mg2+ led to a rapid phospholipase C-dependent intracellular Ca2+ rise, which was inhibited by treatment of cells with pertussis toxin. Western blot analysis and immunocytochemistry of monocytes demonstrated that P2Y(12) receptors, like the beta(2) adrenergic receptor, are localized in lipid raft microdomains. Monocyte stimulation with ATP led to a modest activation of MAP kinase p42/44, which was unaffected by inhibitors of p38 MAP kinase and which did not alter intracellular levels of cyclic adenosine monophosphate or intracellular Ca2+. ATP evoked inhibition of lipopolysaccharide-induced TNF-alpha and IL-1beta secretion, but had no effect on basal secretion of these cytokines. Moreover, ATP-evoked inhibition of TNF-alpha and IL-1beta secretion was blocked by pretreatment of cells with pertussis toxin or wortmannin. Collect